Of note, multiple non-synonymous SNPs (17 and 2, respectively; Supplementary Data 2) were found in the fgd1 and Rv0678 genes, associated with resistance to the newest anti-TB drugs delamanid/pretomanid and bedaquiline, respectively; however, the minimum inhibitory concentrations of ET1291 for all three drugs were below the proposed respective critical concentrations. Here, FGD1 is linked to tuberculosis.