SOAT1 and glioblastoma: Furthermore, by comparing the mRNA levels of SOAT1 in glioma tissues and corresponding normal tissues in a comprehensive dataset (TCGA-GBM plus TCGA-LGG), the mRNA level of SOAT1 in glioma was significantly upregulated, and the expression of SOAT1 increased with an increase in tumor grade (Fig. 1E).