TCGA and GTEx data illustrated that TOP2A expression was significantly upregulated in most cancer types, such as BLCA, CESC, BRCA, CHOL, COAD, ESCA, GBM, HNSC, KICH, KIRC, KIRP, LAML, LIHC, LGG, LUAD, LUSC, OV, PCCG, PRAD, PEAD, SKCM, STAD, TGCT, THCA, UCEC, and UCS, suggesting that TOP2A might function as an oncogene in diverse tumors (Supplementary Figure 4A, 4B). The gene discussed is TOP2A; the disease is cancer.