TOP2A and liver cancer: The results of qRT-PCR and western blot assays indicated that TOP2A mRNA and protein levels were elevated in liver cancer cell lines compared to that in a normal liver cell line, respectively (Figure 9A and Supplementary Figure 7A), among which HCCLM3 cells with high metastatic characteristics showed the highest expression of TOP2A and Hep3B cells also exhibited higher TOP2A expression level.