In this study, we found that EphA2 expression correlated with infiltration of a variety of immune cells, such as neutrophils, myeloid dendritic cells and macrophage cells, but EphA2 expression did not correlate significantly with common immune checkpoints such as PDCD1, CTLA4, and CD274, etc., These results suggest that EphA2 may regulate the development of colorectal cancer by influencing the infiltration of immune cells. The gene discussed is CD274; the disease is colorectal cancer.