According to the results of go and KEGG analysis, we speculated that hsa-mir-503 and hsa-mir-1247 might affect the prognosis of PC from many aspects, such as cell cycle, p53 signaling pathway, JAK/STAT signaling pathway, PI3K/Akt signaling pathway and DNA recombination by regulating these 4 mRNAs. This evidence concerns the gene TP53 and pachyonychia congenita.