eSNPs at MZB1 (marginal zone B and B1 cell specific protein), which is specifically expressed in B cells, correlated with the expression of other B-cell related genes, including immunoglobulins (IGH, IGK, IGL), CD79A (which has previously been associated with joint destruction in RA,16TNFRSF17,17FCRL518 and POU2AF1 (figure 3B). The gene discussed is POU2AF1; the disease is rheumatoid arthritis.