Previous studies suggest that IL-27 regulates ectopic lymphoid structure formation in RA synovium.43 Following protein set enrichment, several histone pathways were found to be significant, which is indicative of an epigenetic effect, and is in keeping with previous reports of epigenetic abnormalities revealed in RA synovial fibroblasts.35 Additionally, IL27 and IL35 mediated pathways were upregulated, as well as regulation of haemopoiesis. The gene discussed is IL27; the disease is rheumatoid arthritis.