Additionally, diseases associated with changes in IP3R expression, for example, spinocerebellar ataxia (52), atherosclerosis (62), various liver disorders (63), and multiple cancer types including uveal melanoma, mesothelioma (64), colorectal carcinoma (65), and breast cancer (66, 67), could also have a secretory component to their pathophysiology. This evidence concerns the gene ITPR3 and atherosclerosis.