A study involving 228 individuals with SCAD (130 in the discovery cohort and 98 in the replication cohort) implicated a set of 10 collagen genes (COL3A1, COL5A1, COL4A1, COL6A1, COL5A2, COL12A1, COL4A5, COL1A1, COL1A2, and COL27A1) as significantly enriched for rare, deleterious variants in aggregate compared to 46,559 UK Biobank controls, when analyzing a selected candidate set of genes based upon 2506 genes expressed in the coronary arteries in GTEx [55•]. Here, COL5A1 is linked to spontaneous coronary artery dissection.