In this cohort of individuals with SCAD with the defined high-risk features, there was additional enrichment for rare variants in genes prioritized by genome-wide association studies of SCAD, as well as genes prioritized by statistical analyses leveraging large databases of arterial tissue gene expression at the mRNA level, in the NIH genotype-tissue expression (GTEx) database, employing colocalization analysis (strongly prioritized genes were ADAMTSL4, LRP1, and PHACTR1) [32•]. The gene discussed is PHACTR1; the disease is spontaneous coronary artery dissection.