Additionally, these two cell lines show other different features (i.e., T47D are p53 mutant, whereas MCF7 are p53 wild type) that could explain the different responses we observed after Cd exposure [35, 36].The results of the present research further corroborate our previous data showing that Cd can modulate ERα expression not only in MCF7 cells, but also in another Luminal A BC cellular model system as T47D, suggesting that ERα alteration upon the exposure to this pollutant is a widespread event in BC cells. The gene discussed is ESR1; the disease is breast cancer.