AKT1 and familial pancreatic carcinoma: EV-derived miRNAs have been reported to promote angiogenesis in several cancers, such as miR-17-5p in nasopharyngeal carcinoma via AKT/VEGF-A signaling [202], miR-205 in ovarian cancer through the PTEN/PI3K/AKT pathway [203], miR-27a in pancreatic cancer through targeting of the BTG2 tumor suppressor [204], and miR-105 in breast cancer via targeting of the tight junction protein zonula occludens-1 leading to vascular permeability [205].