The effect of salpingitis on eggshells in the MLP-LPS group might be mitigated by down-regulating CHGA and up-regulating KLHL1 and CNPE4. In summary, Lactiplantibacillus plantarum prevented salpingitis by inhibiting the expression of inflammatory genes, promoting the expression of anti-tumor genes, and increasing the expression of calcium-regulated genes. The gene discussed is KLHL1; the disease is neoplasm.