It has been identified as a novel receptor for the adhesion of spotted fever group Rickettsia and Staphylococcus aureus to vascular endothelial cells [56] and is known to interact with the CARDS toxin of Mycoplasma pneumoniae, promoting host cell vacuolization [57], and heat shock protein GroEL of Mycoplasma gallisepticum interacts with ANXA2, facilitating host infection [58]. The gene discussed is ANXA2; the disease is infection.