Hemophilia is rare in females due to the presence of two X chromosomes; however, exceptions include: homozygosity of the hemophilia gene, extreme X-chromosome inactivation in a heterozygote, and a single X chromosome (Turner syndrome) [3, 4].The combined deficiency of coagulation factors V and VIII is a rare autosomal recessive disease with a frequency of 1 in 1,000,000. This evidence concerns the gene F5 and hemophilia.