IGKV1D-22 and Sepsis: Due to the embryonic lethality observed in S100A8-deficient mice and the lack of S100A8/A9 protein expression in S100A9-deficient mice [22], S100A9 knockout (KO) mice were used in this study to explore the role of S100A8/A9 in sepsis-induced pulmonary vascular hyperpermeability.