The most common CC items were focal adhesion, cell-substrate junction and cell leading edge; the most common MF items were cadherin binding, ligase activity and molecular adaptor activity; the most common BP items were golgi vesicle transport, protein folding and regulation of supramolecular fiber organization (Fig. 7B); the most implicated pathways were endocytosis, valine, leucine and isoleucine degradation, proteasome, bacterial invasion of epithelial cells and amyotrophic lateral sclerosis (Fig. 7C). The gene discussed is CDH17; the disease is amyotrophic lateral sclerosis.