We checked the expression levels of CDK6, TNRC6B, AGO1, AGO3, and TNRC6A in PCa tissues, based on data from 465 prostate tumour samples obtained from TCGA-PRAD database, and stratified according to the 2014 ISUP-GG [14] into low-risk (ISUP I and II) and high-risk (ISUP III, IV, and V). This evidence concerns the gene AGO1 and posterior cortical atrophy.