In the present study, we revealed 4 deregulated PCa cell exomiRNAs can epigenetically control the TNRC6B gene, showing to be useful for PCa diagnosis; whereas TNRC6B, CDK6, and AGO1 were found to be potentially regulated by 7 PCa cells exomiRNAS in PCa tissue tumours according to tumor grade and, may be useful for PCa prognosis purposes. This evidence concerns the gene AGO1 and posterior cortical atrophy.