SLC39A14 and central nervous system cancer: However, after treatment with erastin + fer-1 or fer-1, there was no significant difference in cell viability between the si-NC group and the si-SLC39A14 group in both U251 and LN229 cells, suggesting that the knockdown of SLC39A14 had a significant impact on erastin-induced ferroptosis in glioma cells (Fig. 6A).