IREB2 and renal cell carcinoma: In our study, we identified seven ferroptosis-related genes through bioinformatics analysis, including SLC39A14, WWTR1, STEAP3, NOTCH2, IREB2, HIF1A, and FANCD2.WWTR1 (also known as TAZ) is a transcriptional coactivator involves in the Hippo signaling pathway and affects the progression of multiple tumors by regulating ferroptosis, including renal cell carcinoma [32, 33] and epithelial ovarian cancer [34].