The neutrophil to lymphocyte ratio(NLR) is an easily obtained serum measure that corresponds to systemic inflammation and has been demonstrated to be a valuable prognostic indicator in different types of malignancies [11, 12], inflammatory disease [13], and chronic liver diseases [14–16], However, it is not yet clear whether NRL is associated with poor therapeutic response in PBC patients. The gene discussed is NRL; the disease is primary biliary cholangitis.