Epidermal growth factor receptor kinase substrate 8 like 3 (EPS8L3) has reported in various cancers, sunch as live cancer, pancreatic cancer and gastric cancer, which involved in regulating cell proliferation, differentiation and migration [36–38].The expression of EPS8L3 is markedly up-regulated in liver cancer tissues and cell lines, and patients with high expression of EPS8L3 have shorter survival [36, 39]. Here, EPS8L3 is linked to liver cancer.