After correcting for age, NYHA class, heart rate, systolic BP, diastolic BP, WBC, CRP, ALT, AST, uric acid, eGFR, sodium, chloride, and lg BNP, the multivariate Cox proportional hazards analyses showed that the ALI and GNRI were independent predictors of all-cause death in patients with HF. The gene discussed is CRP; the disease is hydrops fetalis.