P2RY12 and Alzheimer disease: In accordance with these publications, we observed a significant upregulation of genes that define the AD-associated microglia including subsets involved in lipid metabolism and chemotaxis (e.g. Fgf13, Myo1e, Igf1, Ccl3, Ctnna3, Ank), with a corresponding downregulation of homeostatic genes (e.g. Tmem119, P2ry12 and Cx3cr1; Fig. 2G and Additional file 1: Fig. S5).