As expected, cluster B cells are strongly enriched for expression of gene module Mg.G2 (529 genes) which consists of genes associated with AD and expressed in DAMs (e.g. Ank, Lpl, Csf1, Igf1, Itgax; Fig. 3A,D–G) [30, 52]. The gene discussed is ITGAX; the disease is Alzheimer disease.