Fibrillar collagen receptor disc domain receptor 2 (DDR2), which is also related to metastasis in tumors and tumor stromal cells, may also play an important role in metastasis; for example, studies have found that DDR2 is activated in CAFs, and depletion of DDR2 in CAFs leads to decreased ECM production and altered collagen structure [106]. The gene discussed is DDR2; the disease is neoplasm.