HMGCR and familial hypercholesterolemia: This is not only because intracellular cholesterol flux is so critical for the invasive behavior of cancer cells and cancer progression in general, but also because many cholesterol-regulating drugs, such as HMGCR inhibitors (statins), cholesteryl ester transfer protein (CETP) inhibitors, and niacin derivatives have already been developed and are used clinically for other disorders such as hypercholesterolemia.