Based on the method of network pharmacology, we found that there were 15 common genes in atherosclerosis and NSCLC, including CD163, MMP9, ACP5, FABP4, EMCN, CD52, NPR1, MMP12, C2, ITLN1, FHL5, CD36, FIBIN, C7, and NPNT. Here, NPNT is linked to atherosclerosis.