Based on the method of network pharmacology, we found that there were 15 common genes in atherosclerosis and NSCLC, including CD163, MMP9, ACP5, FABP4, EMCN, CD52, NPR1, MMP12, C2, ITLN1, FHL5, CD36, FIBIN, C7, and NPNT. The gene discussed is NPR1; the disease is non-small cell lung carcinoma.