AKT1 and Alzheimer disease: Moreover, WGX50 also inhibits neuroinflammation induced by the amyloid-beta (Aβ) peptide in microglia via 7nAChR activation of the JAK2/STAT 3 and PI3K/AKT pathways, which may be a hopeful therapeutic molecular compound against Alzheimer’s Disease (AD) [31–34].