After including age, tumor stage, cancer status, residual tumor, chemotherapy, and targeted therapy as adjustment factors in the Cox proportional hazards regression models, the results of the multivariate survival analysis showed that high expression of the genes CST2, CST4, and CST5 significantly decreased OS (adjusted P = 0.030, HR = 1.57, 95% CI = 1.05–2.35; adjusted P = 0.010, HR = 1.69, 95% CI = 1.13–2.51; adjusted P = 0.001, HR = 1.94, 95% CI = 1.29–2.91, respectively; Table 1). The gene discussed is CST5; the disease is cancer.