We were the first to analyze and find the differences of m6A-related genes between pulpitis and normal groups, among which ALKBH5, METTL14, METTL3, METTL16, RBM15B and YTHDF1 were significantly different, suggesting that these genes may be involved in the occurrence of pulpitis important role in development. The gene discussed is METTL16; the disease is pulpitis.