TP53 and osteosarcoma: TP53 loss (evolvability contributing to increased adaptations)6, RAS pathway gains (foraging and intake of carbohydrates and amino acids)2, an abnormal cell cycle with CMG helicase wild type status (DNA replication and never genes)39–41, and MYC (resistance)13,42 capture common and recurrent genetic changes in osteosarcoma.