EPAS1 and colorectal carcinoma: We analyzed the expression of genes in tumor and normal samples, and the results showed that NDUFS1, NDUFS2, NDUFC1, and EPAS1 were downregulated in CRC, and SLC7A11, OXSM, LRPPRC, NDIFA11, NUBPL, and CONT1 were upregulated in CRC (Fig. 2A).