SLC7A11 and neoplasm: Previous studies have found that to counteract oxidative stress in unfavorable survival environments, tumor cells transport cystine intracellularly via high expression of the cystine transporter solute carrier family 7 member 11 (SLC7A11) to feed antioxidant molecules, such as GSH, a process that is highly dependent on NADPH produced by the pentose phosphate pathway7.