In a study on human systemic lupus erythematosus [27], some variants reside in conserved elements within the 3’ UTR (rs10954214, rs10954213) and the rs10954213 G allele is predicted to disrupt a polyA signal sequence downstream of the stop codon of IRF5 in the 3’UTR region of exon 9, therefore playing a role in mRNA expression and stability. Here, IRF5 is linked to systemic lupus erythematosus.