Given the relevance that exacerbated inflammation and oxidative stress has on the progression of neurodegenerative diseases, including those affecting the retina, we evaluated the effect of the secretome -conditioned medium- of LPS-activated and QUE-, NAR- or RAN- pre-treated BV2 microglia cells on the viability of 661W photoreceptor-like cell line. The gene discussed is CPSF4; the disease is neurodegenerative disease.