Further, we used Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis, and Lipopolysaccharide (LPS) to infect/stimulate Sept2fl/flLyz2-Cre PMs, and found no significant difference in M1-like polarization between SEPT2-deficient and WT macrophages upon E.coli and Listeria infection or LPS stimulation. Here, SEPTIN2 is linked to listeriosis.