SEPTIN2 and viral infectious disease: Considering that stress sensors induce unfolded protein responses (UPR) after the recognition of unfolded/misfolded proteins, we used the NTPAN-MI probe42 (Supplementary Fig. 5f) to indicate the unfolded proteins, and the results showed that SEPT2 deletion resulted in a more substantial enrichment of unfolded proteins upon viral infection than the control (Fig. 2d, e).