Cutaneous vascular lesions are a common hallmark of developmental vascular disorders such as RASA1- and EPHB4-mutated CM-AVM25,27, ENG1- and ACVRL1-mutated HHT29, and RASA1-mutated Parkes Weber syndrome, among others30,118,119. Here, EPHB4 is linked to capillary malformation-arteriovenous malformation 1.