These include several cases of autosomal dominant (AD) capillary malformation-AVM syndrome types 1 and 2 (CM-AVM1/2), caused by RASA1 variants (OMIM: 608354)27 or EPHB4 variants (OMIM: 618196)25, and single VOGM cases in AD hereditary hemorrhagic telangiectasia type 1 and 2 (HHT1/2) caused by variants in ENG (OMIM: 187300)28 or ACVRL1 (OMIM: 600376)29. Here, ENG is linked to cutaneous mastocytosis.