Rats with diabetes induced by a high-fat diet exhibit low levels of AKT and p-AKT in retinal tissues, and this low expression is accompanied by the induction of ROS and decreased phosphorylated mammalian target of rapamycin (mTOR) and nitric oxide synthase, which synthesize NO and affect vascular permeability [8, 9]. This evidence concerns the gene AKT1 and diabetes mellitus.