PLD3 has a high expression level in the p53 wild-type breast cancer cell lines MCF7, and CAL51 (p53wt) and a low expression level in the p53 mutant MDA-MB-231 and p53 deleted CAL51 (p53KO) breast cancer cell lines (Fig. 3C), indicating that p53 may be responsible for regulating PLD3 expression. This evidence concerns the gene TP53 and breast carcinoma.