PLD3 and breast cancer: PLD3 has a high expression level in the p53 wild-type breast cancer cell lines MCF7, and CAL51 (p53wt) and a low expression level in the p53 mutant MDA-MB-231 and p53 deleted CAL51 (p53KO) breast cancer cell lines (Fig. 3C), indicating that p53 may be responsible for regulating PLD3 expression.