The inhibition of AChE activity reduces the cleavage of the acetylcholine into choline and acetate, and consequently increases acetylcholine in the synaptic cleft (Thapa et al. 2017), leading to symptoms such as paralysis that can progress to convulsions or cardiac and respiratory depression, potentially resulting in death (Tilton et al. 2011). This evidence concerns the gene ACHE and Respiratory insufficiency due to muscle weakness.