In addition, understanding the alternative splicing of Kirrel3 may facilitate the study of disease mechanisms that involve this synaptic gene because human Kirrel3 missense variants have been repeatedly identified as risk factors for neurodevelopmental disorders including autism spectrum disorders and intellectual disabilities (Bhalla et al., 2008; De Rubeis et al., 2014; Iossifov et al., 2014; T. Wang et al., 2016; Yuen et al., 2016; Li et al., 2017; Kalsner et al., 2018; Guo et al., 2019; Leblond et al., 2019; Hildebrand et al., 2020; Taylor et al., 2020; Zhou et al., 2022). This evidence concerns the gene KIRREL3 and Intellectual disability.