Pan-cancer analyses of >10,000 samples in TCGA also revealed a number of SUGP1 cancer-associated mutations flanking the SUGP1 G-patch motif (G-patch) that partially recapitulate mutant SF3B1 missplicing, suggesting a mechanistic link between SF3B1 and SUGP1 (Liu et al. 2020; Alsafadi et al. 2021). This evidence concerns the gene SF3B1 and cancer.