Fig 3D shows the Kaplan–Meier plot for the 1,603 ER+ breast cancer patients treated with adjuvant endocrine therapy alone. The 5-yr Kaplan–Meier survival rates for patients with low, medium, high, and very high Cosinet levels were 73.9% (95% CI: 65.9–82.8%, n = 144), 84.0% (95% CI: 80.7–87.4%, n = 588), 90.9% (95% CI: 88.5–93.4%, n = 732), and 98.4% (95% CI: 96.2–100.0%, n = 142), respectively (P = 7 × 10−11, log-rank test). Here, ESR1 is linked to breast cancer.