In the present study, the authors evaluated the effect of HBO on oxidative stress in a trinitrobenzene sulfonic acid (TNBS) experimental model of inflammatory bowel disease and examined the inflammatory cytokine profile and activity of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). This evidence concerns the gene GSR and inflammatory bowel disease.