SMYD3 and posterior cortical atrophy: To determine the role of SMYD3 in oncogenic properties of PCa cells, we generated PC-3 and LNCaP stable cell lines expressing short hairpin SMYD3 (shSMYD3) that targets the 3′ untranslated region (3′UTR) of SMYD3 under control of a doxycycline-inducible promoter (Tet-on).