WNK2 and posterior cortical atrophy: Aberrant signaling in critical pathways, such as the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (2), p53 (3), MYC (4), and RAS/RAF/mitogen-activated protein kinase (MAPK) (5, 6) signaling pathways, promotes PCa aggressiveness in vitro and metastatic spread in vivo.