Evaluation of SMYD3 expression in primary prostate tumors from The Cancer Genome Atlas (TCGA) database (29) compared to tumor-adjacent (TCGA) or normal prostate tissue [Genotype-Tissue Expression (GTEx)] showed a significant increase in SMYD3 mRNA levels in tumor samples (Fig. 1A), similar to additional independent datasets of primary prostate tumors [Fig. 1A (30, 31)]. The gene discussed is SMYD3; the disease is neoplasm.