HMGCR and breast cancer: In vitro statins cause cell cycle arrest by blocking DNA replication phase.11 In BC cells, statins have anti-invasive and antiangiogenic effects12 and induce apoptosis through HMG-CoA reductase inhibition.13 Previous studies, including a Finnish population-based cohort study, suggest that statins are associated with improved BC survival5,6,7; however, a large systematic review found that the pooled association was not robust and was heterogeneous.8 It has been suggested that statins may be beneficial for BC survival in patients with metastatic disease.9