3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme in the mevalonate pathway, which produces cholesterol and nonsteroidal isoprenoid compounds.4 The HMG-CoA reductase inhibitors, commonly known as statins, are well-tolerated drugs and widely used in primary and secondary prevention of cardiovascular disease (CVD). The gene discussed is HMGCR; the disease is cardiovascular disorder.