Secondly, we interrogated patient-derived data using the R2 platform (www.r2.amc.nl) and confirmed that OTX2-AS1 expression is significantly upregulated in WNT, G3, and G4 medulloblastoma compared to SHH medulloblastoma (p < 0.0001, Fig. 1c). This evidence concerns the gene OTX2 and medulloblastoma.