By exploring DNA methylation data from tumor tissues [6], we found increased methylation of the promoter of OTX2/OTX2-AS1 in SHH medulloblastoma compared to WNT, G3 and G4 medulloblastomas, which may contribute to the low expression of these two genes in the SHH group (Fig. 1f). The gene discussed is OTX2; the disease is medulloblastoma.