IMPG2 and respiratory distress syndrome in premature infants: To determine if the mutations in our Impg2 mouse models differentially impact protein expression and lead to pathology associated with IRDs, we generated two novel antibodies to specifically immunolabel either the intracellular (IC-IMPG2) or extracellular (EC-IMPG2) domain of IMPG2 (see Fig. 1B for antibody immunogen sites).