Human genetic studies have also suggested a link between interferon responses and COVID-19 outcomes, with one group finding 3.5% of patients with severe COVID-19 to harbor rare variants in interferon signaling genes (including IFNAR1, IFNAR2, IRF3, and IRF7) (55), though this finding was not replicated in other studies (56, 57). This evidence concerns the gene IFNAR2 and COVID-19.