In line with this evidence, the previous comparative analysis of CAFs was isolated from different tumors (breast cancer skin metastasis, cutaneous basal cell carcinoma, squamous cell carcinoma arising from oral cavity mucous membrane, and melanoma) and found that the effect of CAFs on EM-G3 cells is rather tumor unspecific (each studied culture of CAFs induced co-expression of keratins-8/-14 in the EM-G3 cells) (22). The gene discussed is KRT8; the disease is squamous cell carcinoma.