IL6 and neoplasm: To confirm that the inhibition of IL‐6 production by TAMs is involved in the antitumour activity of calycosin, we isolated and purified macrophages from xenografted tumours and found that the IL‐6 mRNA level in these TAMs was downregulated in the calycosin group compared to those in the control group, as revealed in the RT‐PCR assay (Figure 7C).