Several studies reported that PD‐L1 and CD47 also played a vital role in regulating immune‐unrelated biological processes in tumour cells, moreover, antagonising PD‐L1 or CD47 could inhibit the tumour cell proliferation and migration and induce apoptosis (Azarbarzin et al., 2021; Clark et al., 2016; Hu et al., 2020; Kong et al., 2020; Zhang et al., 2020). The gene discussed is CD274; the disease is neoplasm.