TXN and malaria: To investigate the effect of PfK13 protein mutation on various metabolic processes in Plasmodium, we analyzed the expression of genes associated with glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway (PPP), oxidative phosphorylation, reproduction, DNA replication, pyrimidine metabolism, fatty acid metabolism, amino acid metabolism, purine metabolism, and redox pathways, including the glutathione and thioredoxin systems (Fig. 3; Additional file 1: Fig. S1), which have often been associated with drug resistance in malaria parasites [30].