Four patients exhibited walking aid dependency at an average age of 33.3 years (one patient each with LGMD-R1-calpain3-related, dysferlinopathy, LGMD-R9-FKRP-related and LGMD-R18-TRAPPC11-related). This evidence concerns the gene FKRP and neuromuscular disease caused by qualitative or quantitative defects of dysferlin.