CRPPA and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: Four patients had a loss of ambulation and developed wheelchair dependence, two of whom had dysferlinopathy, with a mean age of 56 years; one had LGMD-R1-calpain3-related and was 38 years old; and one had LGMD-R20-ISPD-related and was 21 years old.