Most of the patients with LGMD-R1-calpain3-related, dysferlinopathy and LGMD-R7-telethonin-related exhibited muscle weakness after the age of 15 years, and 8/15 (53.3%) patients with LGMD-R1-calpain3-related, 12/18 (66.7%) patients with dysferlinopathy and 4/7 (57.1%) patients with LGMD-R7-telethonin-related had an age of onset after 19 years; the mean ages of onset were 20.9 ± 7.6 years for patients with LGMD-R1-calpain3-related, 24.4 ± 8.1 years for patients with dysferlinopathy and 22.6 ± 7.7 years for patients with LGMD-R7-telethonin-related (P > 0.05). The gene discussed is TCAP; the disease is neuromuscular disease caused by qualitative or quantitative defects of dysferlin.