Except for one patient with asymptomatic hyperCKemia, all of the patients had different degrees of proximal lower limb weakness, and 14 of the patients had no involvement of the proximal upper limbs, eight of whom had dysferlinopathy, one had LGMD-R1-calpain3-related, four had LGMD-R7-telethonin-related, and one had LGMD-R10-TTN-related. The gene discussed is TTN; the disease is neuromuscular disease caused by qualitative or quantitative defects of dysferlin.